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Dan works at the intersection of social science, genomics, and public health. His recent work has focused on development and evaluation of methods to quantify the pace and progress of biological processes of aging in young and midlife humans and the application of these methods to study (1) how life-history and social factors contribute to individual differences in healthy aging; and (2) whether and how aging processes can be modified by intervention.His work is supported by the National Institute On Aging, The Russel Sage and Jacobs Foundations, and the Canadian Institute for Advanced Research. With Terrie Moffitt and Avshalom Caspi he originated the Pace of Aging Method to quantify the aging process from longitudinal analysis of human physiology and recently translated this method into aDNA-methylation blood test, DunedinPACE, that can be implemented from a single time point of data collection. Since 2020, he has been named an ISI highly-cited researcher.